The title is a reference to the often-misquoted advice of Arthur Quiller-Couch, that writers must be willing to edit out their most finely written passages if they fail to serve the piece as a whole: "Murder your darlings."
The story is about the college days of some of the early members of the Beat Generation (Lucien Carr, Allen Ginsberg, William S. Burroughs, and Jack Kerouac), their interactions, and Carr's killing of his long-time friend David Kammerer in Riverside Park in Manhattan, New York City.
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